In collaboration with our industrial partner, nanoparticles have been prepared, which are biocompatible
biopolymers and can form stable complexes with Gd ions. Our goal is to prepare nanoparticles, which
are able to target specific (tumor) cells, tissues by receptor-mediated cellular uptake. This project aims at
pursuing our collaboration with BBS with the modification of these nanoparticles for PET. Since our
nanoparticles are composed of NH2-rich constituent, we will explore coupling with 18F- labelled synthons,
and with radioactive metal complex. Testing will involve different imaging modalities e.g. PET, SPECT
or MR. MRI/PET modalities allow for the fusion of images presenting anatomical and functional data using
software developed at UD. The conditions can be found on the EU research portal: http://ec.europa.eu/research/
under the title “Marie Curie Initial Training Networks 2012 (ITN)”
Submissions are accepted from university graduates (M.S. or equivalent) in chemistry or related fields.
The applicant should come from a foreign country, having spent less than 12 months in Hungary during
the last 3 years. Fluency in written and spoken English is required.
Contact person: Pal Mikecz;
About the RADIOMI Project: The RADIOMI network research objective is to pool the expertise of
nine leading experts to provide a coordinated first class training program to produce new talent
and innovation in radiochemistry for MI.
The emphasis of this network is on training scientists able to
develop and perform innovative radiolabeling with the short half-life positron emitting isotopes 18F (109.8
mins), 11C (20.4 mins) and 13N (10 mins). These new and improved methods will be trialed in the
synthesis of known and new radiotracers (small molecules notoriously difficult to prepare and/or to access
in a pure form, with the required quality or in a reproducible, peptides, libraries of labeled compounds)
manner. Preclinical evaluation will be carried out on selected tracers. In the process, the network will
provide state-of-the-art training opportunities in chemistry, radiochemistry, nuclear physics, microfluidic
and flow technology, pharmacology, (pre)clinical imaging (oncology, Central Nervous System), multimodal
imaging, all key disciplines for radiopharmaceutical development and nuclear medicine but also related to
health physics, all having a major impact on society’s welfare.